How to Add Lactase Drops to Baby Formula and How Long to Wait

The bottle is ready, your baby is getting impatient, and you’re holding a bottle of lactase drops. Should you add them now or wait a little longer? It’s a familiar question for parents using lactase drops for babies. Here’s how to add lactase drops to infant formula, what milk temperature is suitable for the enzyme and how long to wait before feeding.
What Is Lactase and Why Is It Added to Baby Formula?
Lactase is an enzyme that breaks down lactose, the natural sugar found in breast milk and most infant formulas, into glucose and galactose. Breast milk contains approximately 7 g of lactose per 100 ml.
When lactase activity is lower, some lactose may pass into the large intestine, where bacteria ferment it. This process may be accompanied by gas and tummy rumbling after feeding.
Learn more in our article about lactase deficiency and lactose intolerance in babies.
What Temperature Should Baby Formula Be for Lactase Drops?
Warm milk, at approximately 36–37°C (97–99°F), is suitable for adding lactase drops. Lactase is a protein-based enzyme, so excessive heat can change its structure and reduce its activity.
The WHO recommends preparing powdered infant formula with water at a temperature of at least 70°C. Therefore, lactase drops should only be added once the prepared formula has cooled to feeding temperature.
A few drops on the inside of your wrist should feel warm, not hot. A thermometer provides a more accurate reading.
How to Add Lactase Drops to Baby Formula: 5 Steps
- Prepare the infant formula according to the manufacturer’s instructions.
- Allow it to cool to approximately 36–37°C.
- Measure the required number of Mamalac drops using the dosage chart on the packaging. The amount depends on your baby’s age and the volume of milk.
- Close the bottle and gently mix the contents.
- Follow the product’s instructions regarding any waiting time before feeding.
How Long Should You Wait After Adding Lactase Drops?
The waiting time depends on the specific lactase product. Some products require a longer period for the enzyme to interact with the lactose in the milk.
Mamalac instructions describe adding the drops to properly prepared infant formula before feeding. Always follow the directions provided with the product rather than assuming that all lactase drops work in exactly the same way.
| Common mistake | What to do instead |
| Adding drops to hot formula | Cool the milk to approximately 36–37°C first |
| Preparing bottles far in advance | Prepare feeds according to infant formula safety guidelines |
| Guessing the number of drops | Follow the dosage chart on the packaging |
Lactase Drops vs Lactose-Free Formula: What’s the Difference?
Lactose-free baby formula is manufactured without lactose, while lactase enzyme drops can be added to regular infant formula or expressed breast milk.
These are different approaches to feeding. If you’re wondering whether lactase drops or lactose-free formula are more suitable for your baby, discuss the options with your paediatrician.
How Long Can You Give Lactase Drops to a Baby?
Mamalac is intended for use during feeding in the first 3–4 months of life, according to its instructions.
When it is time to discontinue use, the amount may be reduced gradually. The timing and approach should be discussed with your paediatrician.

Mamalac Lactase Drops for Babies
Mamalac is a dietary supplement containing the lactase enzyme.
- 1 ml contains 3,000 ALU of lactase enzyme.
- Suitable for use from the first day of life according to the instructions.
- Neutral taste.
- Can be used with infant formula and breast milk.
Find out more on the Mamalac product page or explore the Vorwarts Pharma product range — quality dietary supplements for the whole family.
Frequently Asked Questions About Lactase Drops for Babies
How long should I wait after adding lactase drops to formula?
Follow the instructions for your specific product. Waiting times can vary between lactase brands.
Can I add lactase drops to hot baby formula?
No. High temperatures can damage the lactase enzyme. Always allow the prepared formula to cool before adding the drops.
How can I check the temperature of baby formula?
Place a few drops on the inside of your wrist. The milk should feel warm, not hot. A thermometer is recommended for checking the exact temperature.
Can I warm formula after adding lactase drops?
It is better to warm the formula first, then add the drops once it has reached a suitable temperature. Avoid exposing the enzyme to excessive heat.
Can I prepare formula with lactase drops in advance?
Prepare feeds according to the formula manufacturer’s safety instructions. Fresh preparation is generally preferred. Discard leftover formula within the recommended time limits.
Should I add lactase drops to every feeding?
According to the Mamalac instructions, the drops are used during each feeding in the first 3–4 months of life. Follow the recommended dosage chart.
Can lactase drops be added to expressed breast milk?
Yes. Mamalac can be added to expressed breast milk according to the instructions. For direct breastfeeding, the measured drops can be given on a previously sterilised spoon before feeding.
Do lactase drops change the taste of formula?
Mamalac has a neutral taste, making it suitable for adding to your baby’s usual milk.
At what age can babies use Mamalac lactase drops?
Mamalac can be used from the first day of life according to its product instructions.
How long does an opened bottle of Mamalac last?
Use Mamalac within 3 weeks of opening. Store it in its original packaging below 25°C, away from heat, sunlight and the reach of children.
Source on water temperature: WHO/FAO 2007 Guidelines for the Safe Preparation, Storage and Handling of Powdered Infant Formula.
A dietary supplement should not be used as a substitute for a varied and balanced diet.